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Endoscopic Sleeve Gastroplasty in 109 Consecutive Children and Adolescents With Obesity: Two-Year Outcomes of a New Modality.

Endoscopic Sleeve Gastroplasty in 109 Consecutive Children and Adolescents With Obesity: Two-Year Outcomes of a New Modality.

Alqahtani A, Elahmedi M, Alqahtani YA, Al-Darwish A.
Am J Gastroenterol. 2019
Abstract
OBJECTIVES:
Endoscopic sleeve gastroplasty (ESG) uses full-thickness sutures that restrict the stomach to a sleeve-like configuration. There
is no published evidence on endoscopic tissue apposition techniques in pediatric patients. In this article, we report our ESG
experience with the first 109 pediatric patients with obesity who underwent ESG under our care.


METHODS:
ESG was offered as a day-case procedure under a standardized protocol and clinical pathway that included surgical, medical,
and endoscopic modalities for the treatment of pediatric and adult obesity. ClinicalTrials.gov Identifier: NCT03778697.
RESULTS:
The 109 patients in this study had a baseline body mass index and age of 33.0 ± 4.7 and 17.6 ± 2.2 (range: 10-21) years,
respectively. Ninety-nine (90.8%) were females. The mean procedure time was 61 ± 19 minutes. The mean % total weight loss
at 6, 12, 18, and 24 months was 14.4% ± 6.5%, 16.2% ± 8.3%, 15.4% ± 9.2%, and 13.7% ± 8.0%, respectively. Fourteen
adolescents visited the ambulatory clinic for analgesia. One patient (aged 19.8 years) requested removal
of endoscopic stitches due to abdominal pain, and another underwent Redo-ESG for insufficient weight loss. There were no
blood transfusions, emergency admissions, mortality, or significant morbidity.
DISCUSSION:
In this first study to date on ESG in pediatric patients, we observed that the procedure is safe and effective in children and
adolescents with obesity. Significant weight loss occurs during the first 2 years without mortality or significant morbidity, and
this weight loss seems to be maintained.