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Efficacy and safety of endoscopic sleeve gastroplasty for obesity patients: a meta-analysis.

Efficacy and safety of endoscopic sleeve gastroplasty for obesity patients: a meta-analysis.

Li P, Ma B, Gong S, Zhang X, Li W.
Surg Endosc. 2019 Jun 24.
Abstract
BACKGROUND:
Endoscopic sleeve gastroplasty (ESG) is a minimally invasive, effective, and safe technique for weight loss intervention. Since a
relatively small number of cases were present in previous studies, this study aimed to elucidate the efficacy and safety of ESG.


METHODS:
Relevant publications were identified through searching PubMed, EMBASE, Cochrane, and Web of Science before March 1,
2019. The percentage of total body weight loss (%TBWL), percentage of excess weight loss (%EWL), and the adverse event rate
in each follow-up session were extracted, pooled, and analyzed. Forest plots were graphed based on random effects models.
RESULTS:
A total of 1542 patients from nine studies were eligible for analysis. The pooled results of %TBWL at 1, 3, 6, and 12 months
were 8.78% (p = 0.000), 11.85% (p = 0.000), 14.47% (p = 0.024), and 16.09% (p = 0.063), respectively. The pooled results
of %EWL at 1, 3, 6, and 12 months were 31.16% (p = 0.000), 43.61% (p = 0.000), 53.14% (p = 0.000), and 59.08% (p =
0.015), respectively. Finally, the pooled rate of mild adverse events was 72% (p < 0.01), and the pooled estimate of severe
adverse events was only 1% (p = 0.08).
CONCLUSION:
Although the conventional surgical sleeve gastrectomy is the gold standard for bariatric surgery, ESG could be a promising
minimally invasive alternative for treating obesity with satisfactory efficacy and low risk.